ea0050oc6.5 | Bone, Calcium and Neoplasia | SFEBES2017
Bouker Kerrie
, Andrade Fabia De Oliveira
, Hil Leena
Maternal exposures during pregnancy to endocrine disrupting chemicals increase daughters breast cancer risk in humans and animal models. We have previously found that these exposures also pre-program offsprings mammary tumors to exhibit increased resistance to antiestrogen therapy, and that treatment with valproic acid (HDAC inhibitor) and hydralazine (DNMT inhibitor) prevented antiestrogen resistance. Here we investigated if maternal exposure to ethinyl estradiol ...